Organocatalytic Decarboxylation of Amino Acids as a Route to Bio‐based Amines and Amides.
ChemCatChem 11.17 (2019): 4297-4306. Claes, Laurens, Michiel Janssen, and Dirk E. De Vos.
Link: https://huumeet.info/chem/decarb.pdf

              +----------------------------------------------+
              |                                              |
              |             isophorone (5 mol%)              |
              | tryptophan ====================> tryptamine  |
              |             IPA, 150C, 4 hours               |
              |                                   Yield: 89% |
              +----------------------------------------------+
              |                                              |
              |             isophorone (5 mol%)              |
              |    proline ====================> pyrrolidine |
              |             IPA, 150C, 4 hours               |
              |                                   Yield: 99% |
              +----------------------------------------------+

General procedure for decarboxylation of amino acids.

A 10 mL stainless steel reactor was charged with amino acid (1.25 mmol, 1 eq.),
isophorone (0.0625 mmol, 5 mol%), 2-propanol (5 mL) and a stirring bar, sealed
and heated at 150 °C under magnetic stirring. After 4 h or 24 h the reactor was
cooled to room temperature in an ice bath.

Stainless steel reactor (autoclave) is not required if isopropanol is replaced
with high-boiling point solvent such as DMSO. BP(IPA) = 82.3°C BP(DMSO) = 189°C

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| Shopping list                                                                |
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L-Proline (10 x 1kg)
https://buxtrade.de/en/products/l-prolin

L-Tryptophan (10 x 1kg)
https://buxtrade.de/en/products/l-tryptophan-100-pure-powder

Isophorone (2 x 500mL)
https://www.laboratoriumdiscounter.nl/en/isophorone-970gc-500ml.html

DMSO (2.5L HDPE packaging)
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50-1000ml 22Mpa 350°C High Pressure Reactor Autoclave Mechanical Stirring Heat
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